Publications by authors named "Maximilian Hessenauer"

Article Synopsis
  • Secondary deformities in the midface are common after cleft lip and palate repair, causing functional, aesthetic, and psychosocial issues.
  • Treatment options for patients with midfacial hypoplasia may include autologous and alloplastic maxillary augmentation, depending on individual deformity assessments.
  • A study using CT scans revealed significant variations in maxillary projection in cleft patients, emphasizing the need for precise evaluations to create tailored treatment plans for effective correction of nasomaxillary deformities.
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Due to the limitations of current in vivo experimental designs, our comprehensive knowledge of vascular development and its implications for the development of large-scale engineered tissue constructs is very limited. Therefore, the purpose of this study was to develop unique in vivo imaging chambers that allow the live visualization of cellular processes in the arteriovenous (AV) loop model in rats. We have developed two different types of chambers.

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The arteriovenous (AV) loop model is a key technique to solve one of the major problems of tissue engineering-providing adequate vascular support for a tissue construct of significant size. However, the molecular and cellular mechanisms of vascularization and factors influencing the generation of new tissue in the AV loop are still poorly understood. We previously established a novel intravital microscopy approach to study these events.

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Objective: Transplantation of prefabricated tissue-engineered flaps can be a potential alternative for healing large tissue defects. Providing adequate vascular supply for an engineered tissue construct is one of the key points in establishing successful tissue engineering-based treatment approaches. In tissue engineering-based vascularization techniques like the arteriovenous loop, vascular grafts with high angiogenic potential can help to enhance neovascularization and tissue formation.

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in reconstructive surgery seeks to generate bioartificial tissue substitutes. The arteriovenous (AV) loop allows the generation of axially vascularized tissue constructs. Cellular mechanisms of this vascularization process are largely unclear.

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Intravital microscopy (IVM) study approach offers several advantages over , , and 3D models. IVM provides real-time imaging of cellular events, which provides us a comprehensive picture of dynamic processes. Rapid improvement in microscopy techniques has permitted deep tissue imaging at a higher resolution.

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In advanced inflammatory disease, microvascular thrombosis leads to the interruption of blood supply and provokes ischemic tissue injury. Recently, intravascularly adherent leukocytes have been reported to shape the blood flow in their immediate vascular environment. Whether these rheological effects are relevant for microvascular thrombogenesis remains elusive.

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Background: The incidence of acute cardiovascular complications is highly time-of-day dependent. However, the mechanisms driving rhythmicity of ischemic vascular events are unknown. Although enhanced numbers of leukocytes have been linked to an increased risk of cardiovascular complications, the role that rhythmic leukocyte adhesion plays in different vascular beds has not been studied.

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Carpal tunnel syndrome is a very common condition in hand surgery. The gold standard in therapy is the surgical release of the flexor retinaculum. Endoscopic carpal tunnel release provides superior convalescence and patient safety.

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Rapid implant vascularization is a prerequisite for successful biomaterial engraftment. Vitronectin (VN) is a matricellular glycoprotein well known for its capability to interact with growth factors, proteases, and protease inhibitors/receptors. Since such proteins are highly relevant for angiogenic processes, we hypothesized that VN contributes to the tissue integration of biomaterials.

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Carpal tunnel syndrome is one of the most common diseases in hand surgery. The gold standard in therapy is the surgical release of the carpal tunnel. We provide a brief update on the relevant pathogenesis, diagnosis and therapy and discuss questions related to minimal invasive decompression of the median nerve.

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Article Synopsis
  • Leukocyte recruitment is essential in cardiovascular inflammation, with neutrophils first responding before monocytes amplify the reaction.
  • Advanced microscopy techniques revealed intricate patterns of selectins on immune cells and endothelial cells, guiding their movement to sites of inflammation.
  • The study highlights how different selectins manage the timing and behavior of neutrophils and monocytes during their migration to inflamed tissues, offering fresh insights into immune responses.
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Article Synopsis
  • Rapid fibrovascularization is essential for successful integration of biomaterials, and components of the plasminogen activation system, like uPA and tPA, significantly impact this process.
  • Experiments showed that mice lacking uPA, tPA, or PAI-1 had impaired blood vessel and collagen formation in implants, making it easier to remove these implants than those in normal mice.
  • Coating implants with recombinant versions of uPA, tPA, or PAI-1 enhanced their vascularization, suggesting a potential new method to improve biomaterial integration.
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Objective: Neutrophil infiltration of the postischemic tissue considerably contributes to organ dysfunction on ischemia/reperfusion injury. Beyond its established role in fibrinolysis, tissue-type plasminogen activator (tPA) has recently been implicated in nonfibrinolytic processes. The role of this serine protease in the recruitment process of neutrophils remains largely obscure.

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