Publications by authors named "Maximilian Fascher"

Substance use disorders (SUDs) are severe psychiatric illnesses. Seed region and independent component analyses are currently the dominant connectivity measures but carry the risk of false negatives due to selection. They can be complemented by a data-driven and whole-brain usage of voxel-wise intrinsic measures (VIMs).

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Alcohol use disorder (AUD) has been associated with changes in the processing of internal body signals, known as interoception. Changes in brain structure, particularly in the insula, are thought to underlie impaired interoception. As studies specifically investigating this association are largely lacking, this analysis takes an approach that compares meta-analytic results on interoception with recently published meta-analytic results on gray matter reduction in AUD.

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Article Synopsis
  • Substance use disorders (SUDs) are serious psychiatric issues, and diminished response inhibition may hinder patients’ ability to quit drugs, but existing research on this is inconsistent.
  • The study systematically reviews neuroimaging literature on response inhibition in SUDs, using meta-analysis to better understand functional brain deviations.
  • Results from 21 studies showed some convergence in brain activity, specifically in the right anterior insula, but this finding was not robust, and behavioral data indicated no significant performance differences between SUD samples and controls on inhibition tasks.
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