Publications by authors named "Maximilian E T Hessenauer"
In advanced inflammatory disease, microvascular thrombosis leads to the interruption of blood supply and provokes ischemic tissue injury. Recently, intravascularly adherent leukocytes have been reported to shape the blood flow in their immediate vascular environment. Whether these rheological effects are relevant for microvascular thrombogenesis remains elusive.
View Article and Find Full Text PDFBackground: The incidence of acute cardiovascular complications is highly time-of-day dependent. However, the mechanisms driving rhythmicity of ischemic vascular events are unknown. Although enhanced numbers of leukocytes have been linked to an increased risk of cardiovascular complications, the role that rhythmic leukocyte adhesion plays in different vascular beds has not been studied.
View Article and Find Full Text PDFCarpal tunnel syndrome is a very common condition in hand surgery. The gold standard in therapy is the surgical release of the flexor retinaculum. Endoscopic carpal tunnel release provides superior convalescence and patient safety.
View Article and Find Full Text PDFRapid implant vascularization is a prerequisite for successful biomaterial engraftment. Vitronectin (VN) is a matricellular glycoprotein well known for its capability to interact with growth factors, proteases, and protease inhibitors/receptors. Since such proteins are highly relevant for angiogenic processes, we hypothesized that VN contributes to the tissue integration of biomaterials.
View Article and Find Full Text PDFCarpal tunnel syndrome is one of the most common diseases in hand surgery. The gold standard in therapy is the surgical release of the carpal tunnel. We provide a brief update on the relevant pathogenesis, diagnosis and therapy and discuss questions related to minimal invasive decompression of the median nerve.
View Article and Find Full Text PDFArticle Synopsis
- Leukocyte recruitment is essential in cardiovascular inflammation, with neutrophils first responding before monocytes amplify the reaction.
- Advanced microscopy techniques revealed intricate patterns of selectins on immune cells and endothelial cells, guiding their movement to sites of inflammation.
- The study highlights how different selectins manage the timing and behavior of neutrophils and monocytes during their migration to inflamed tissues, offering fresh insights into immune responses.
Article Synopsis
- Rapid fibrovascularization is essential for successful integration of biomaterials, and components of the plasminogen activation system, like uPA and tPA, significantly impact this process.
- Experiments showed that mice lacking uPA, tPA, or PAI-1 had impaired blood vessel and collagen formation in implants, making it easier to remove these implants than those in normal mice.
- Coating implants with recombinant versions of uPA, tPA, or PAI-1 enhanced their vascularization, suggesting a potential new method to improve biomaterial integration.