Publications by authors named "Maximilian C Volk"
Background: The region of adipose deposition is an important determinant in the outcomes of patients with heart failure (HF). However, the impact of regional adiposity on HF patients undergoing cardiac resynchronization therapy (CRT) remains unclear.
Methods: A retrospective cohort analysis was conducted on 95 patients from a single-center study, assessing post-CRT outcomes.
Article Synopsis
- Skeletal muscle mass (SMM) is important for assessing risks in candidates for transcatheter aortic valve replacement (TAVR), but it's often overlooked compared to traditional measures like weakness or performance.
- A study evaluated three risk models that combined SMM data with frailty assessments to predict complications, rehospitalization, or mortality after TAVR in a cohort of 184 patients.
- Results showed that patients with sarcopenia and those identified as frail had significantly higher rates of adverse outcomes, and incorporating CT-based SMM into frailty assessments improved predictive accuracy for these risks.
Article Synopsis
- Low muscle mass (LMM) is linked to poorer outcomes for patients undergoing transcatheter aortic valve replacement (TAVR), particularly when assessed through advanced imaging technology.
- In a study involving 238 TAVR recipients, 33.6% exhibited LMM, characterized by lower body mass index and grip strength, along with other health markers.
- Patients with LMM experienced higher rates of complications and 2-year mortality, suggesting the potential of using muscle mass assessment from CT scans for better preoperative risk evaluation.
Here, we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaO) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaO nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaO NCs demonstrate high vascular CT contrast, circulation in blood for ∼3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated.
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