MALDI Mass Spectrometry on High-Density Droplet Arrays: Matrix Deposition, Selective Removal, and Recrystallization.

High-density droplet arrays are emerging as a powerful tool for high-throughput bioanalytical applications. These arrays are formed of thousands of nanoliter droplets, which can be analyzed by various optical and spectroscopic methods as well as label-free matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). However, special precautions are required for the massive number of small droplets, particularly in the deposition of matrix compounds.

Continuous Electroformation of Gold Nanoparticles in Nanoliter Droplet Reactors.

Gold nanoparticles (AuNPs) are employed in numerous applications, including optics, biosensing and catalysis. Here, we demonstrate the stabilizer-free electrochemical synthesis of AuNPs inside nanoliter-sized reactors. Droplets encapsulating a gold precursor are formed on a microfluidic device and exposed to an electrical current by guiding them through a pair of electrodes.

3D-printed micro bubble column reactor with integrated microsensors for biotechnological applications: From design to evaluation.

With the technological advances in 3D printing technology, which are associated with ever-increasing printing resolution, additive manufacturing is now increasingly being used for rapid manufacturing of complex devices including microsystems development for laboratory applications. Personalized experimental devices or entire bioreactors of high complexity can be manufactured within few hours from start to finish. This study presents a customized 3D-printed micro bubble column reactor (3D-µBCR), which can be used for the cultivation of microorganisms (e.