Motivation to run measured by progressive ratio tests: Failure to support the addiction hypothesis for rats.

When laboratory rats are given repeated access to an activity wheel, the amount that they run steadily increases. This suggests an analogy with drug dependency in animals and humans, in that this is marked by both increasing intakes of the drug and increasing motivation to obtain the drug (craving). This analogy was examined by measuring motivation to obtain an opportunity to run using a progressive ratio (PR) schedule, whereby the number of lever presses required to release a brake on an activity wheel was increased progressively.