Efficacy of rezafungin in a case of spondylodiskitis.

Rezafungin, which only requires weekly administration, is a potential candidate for difficult-to-treat infections that require long-term antimicrobial treatment, such as bone and joint infections. We report the first case of spondylodiskitis successfully treated with 3 weeks of caspofungin followed by 10 weeks of rezafungin.

Rapamycin and caspofungin show synergistic antifungal effects in caspofungin-susceptible and caspofungin-resistant Candida strains in vitro.

Objectives: Caspofungin is an echinocandin antifungal agent that inhibits synthesis of glucan required for the fungal cell wall. Resistance is mediated by mutation of Fks1 glucan synthase, among which S645P is the most common resistance-associated polymorphism. Rapamycin is a macrolide that inhibits the mechanistic target of rapamycin (mTOR) protein kinase activity.

Effect of a Black Soldier Fly Ingredient on the Growth Performance and Disease Resistance of Juvenile Pacific White Shrimp ().

This study was performed as part of developing a functional feed ingredient for juvenile Pacific white shrimp (). Here we assess the effects of dietary inclusion of a Black Soldier Fly Ingredient (BSFI) from defatted black soldier fly () larvae meal on growth performance, tolerance to salinity stress, and disease resistance when challenged with or a strain of white spot syndrome virus (WSSV). A control diet was used for comparison with three test diets including 4.