Publications by authors named "Maxime Lebrun"
Two new labdane diterpenes, cis-19-hydroxyabienol (1) and 8alpha-hydroxy-12Z,14-labdadien-19-al (2), along with another labdane described for the first time in the genus Larix, 19-acetoxy-13S-hydroxy-8(17),14-labdadiene (3) and a stilbene, 3-methoxy-3,3',5'-trihydroxystilbene (4), were isolated from the stem bark of Larch (Larix laricina). Their structures were established by standard chemical and spectroscopic methods. Compounds 2 and 3 were shown to be moderately cytotoxic against A-549, DLD-1 and normal skin fibroblast cell lines, WS1.
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- Betulinic acid’s low solubility limits its use as an anticancer treatment, prompting researchers to modify it and similar compounds with sugar molecules.
- Synthesis of glycosides led to varying levels of cytotoxicity; adding sugars to betulin reduced its effectiveness, while modifying lupeol significantly increased its potency against cancer cells.
- The study found that the 3-O-alpha-L-rhamnopyranoside form of betulinic acid was particularly effective, making cancer cells much more sensitive than healthy cells, suggesting glycosylated triterpenoids could be promising cancer treatments.
The antibacterial activity of the essential oil of Abies balsamea (balsam fir) was evaluated against Escherichia coli and Staphylococcus aureus. The essential oil of A. balsamea was found to be inactive against E.
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