Publications by authors named "Maxime Le Marois"
Article Synopsis
- - This study examines lesioned fascicles in the sciatic nerves of people with diabetic neuropathy (DN) to understand how these lesions relate to clinical symptoms and their underlying mechanisms.
- - Using advanced imaging and proteomic analysis, researchers found that only individuals with type 2 diabetes (T2D) had these lesions, which showed significant damage like axonal degeneration and demyelination, along with a compromised blood nerve barrier (BNB).
- - The results indicate that while non-lesioned fascicles from T2D donors showed neuroprotective responses, lesioned ones did not and had increased inflammatory activity, suggesting a harmful connection between the liver and nerves that could be targeted for therapy.
The Hippo signaling pathway controls cell proliferation and tissue regeneration via its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ). The canonical pathway topology is characterized by sequential phosphorylation of kinases in the cytoplasm that defines the subcellular localization of YAP and TAZ. However, the molecular mechanisms controlling the nuclear/cytoplasmic shuttling dynamics of both factors under physiological and tissue-damaging conditions are poorly understood.
View Article and Find Full Text PDFAims/hypothesis: The individual risk of progression of diabetic peripheral neuropathy is difficult to predict for each individual. Mutations in proteins that are responsible for the process of myelination are known to cause neurodegeneration and display alteration in experimental models of diabetic neuropathy. In a prospective observational human pilot study, we investigated myelin-specific circulating mRNA targets, which have been identified in vitro, for their capacity in the diagnosis and prediction of diabetic neuropathy.
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