Volume kinetics in a translational porcine model of stabilized sepsis with fluid accumulation.

Background: Fluid dynamics during and after a septic event is complex, but better knowledge could guide both fluid resuscitation and fluid removal. We aimed to compare fluid dynamics before and after sepsis in a clinically relevant mono-bacterial porcine model.

Methods: Twelve sows with a mean body weight of 56 kg were anesthetized, mechanically ventilated, and invasively monitored.