Publications by authors named "Maxime Deslande"
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterised by lipid accumulation in the liver and is often associated with obesity and type 2 diabetes. The gut microbiome recently emerged as a significant player of liver metabolism and health through the production of bioactive compounds that are beneficial for its host - "postbiotics". Circulating hippurate, a host-microbial co-metabolite produced by conjugating microbial benzoate with glycine in the host-liver, is associated with human gut microbial gene richness and with metabolic health.
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- The Cytolethal Distending Toxin (CDT) is a bacterial genotoxin linked to significant foodborne diseases, activating DNA Damage Response and influencing immune responses.
- Chronic exposure to CDT in cells leads to a strong type I interferon (IFN) response through the cytoplasmic sensor cGAS, emphasizing the role of DNA damage recognition.
- The study indicates that CDT exposure causes extensive DNA damage and genetic instability during cell division, with varying effects on immune response based on tissue and cell type, which is crucial for understanding its role in chronic inflammation and cancer development.