Publications by authors named "Maxim Perelman"
Background: Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardiovascular outcomes.
Methods: This nationwide, population-based, retrospective cohort study included all Israeli adolescents 16-19 years of age who were medically evaluated before compulsory military service from 1985 to 2013, including routine blood pressure measurements.
Sarcopenia is characterized by a loss of muscle mass and function and is often associated with frailty, a syndrome linked to physical disability and shortened survival in various patient populations, including cancer patients. Low serum alanine aminotransferase (ALT) values, serving as a biomarker for sarcopenia, were previously associated with frailty and shortened survival in several cancers. In the current study, we aimed to test the association between low ALT and shorter survival in renal cell carcinoma (RCC) patients and survivors.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitors (ICIs) have revolutionized the prognosis of cancer. Diabetes mellitus (DM) has been shown to have a negative effect on patients treated with ICIs. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are effective antidiabetic therapies associated with reduced all-cause mortality and cardiovascular (CV) outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Sarcopenia, marked by loss of muscle mass and function, is linked to frailty and increased risks of falls, fractures, and physical disability, especially in cancer patients.
- A study analyzed 3,075 bladder cancer patients and found that those with low alanine aminotransferase (ALT) levels, indicating sarcopenia, had significantly lower muscle mass and were older with poorer health metrics.
- The results suggest that low ALT values are associated with a 22% increased mortality risk in bladder cancer patients, highlighting the importance of monitoring muscle health in cancer care.
Article Synopsis
- Sarcopenia, characterized by loss of muscle mass and function, is linked to frailty and shorter survival rates in cancer patients, with low alanine aminotransferase (ALT) indicating muscle loss.
- This study retrospectively analyzed prostate cancer (PCa) patients to explore the correlation between low ALT levels and reduced survival.
- Results showed that low ALT levels (below 17 IU/l) were associated with a significant increase in mortality risk, highlighting the importance of muscle mass in cancer prognosis.
Article Synopsis
- The study aimed to determine if low complement levels in patients with positive anti-phospholipid antibodies can predict worse health outcomes, focusing on mortality and complications during hospitalization.
- Researchers examined the medical records of over 6,800 hospitalized patients with abnormal anti-phospholipid antibodies and complement levels between 2007 and 2021, finding that those with low complement levels had significantly higher mortality rates.
- The results indicate that low complement levels are an independent predictor of higher mortality, aligning with recent findings about the importance of complement activation in anti-phospholipid syndrome.
Article Synopsis
- Patients in general wards face a risk of deterioration, and tools for early detection, like remote patient monitoring (RPM), can help healthcare providers intervene promptly.
- This study evaluated a new wearable RPM device in a large medical center to see if it could provide timely alerts for patients at high risk of deterioration.
- Out of 410 patients recruited, 217 were analyzed, showing that the RPM device's scoring system effectively alerted medical staff about impending clinical deterioration in the majority of cases before it occurred.*