Publications by authors named "Maxim Korolev"
Article Synopsis
- - Osteopoikilosis (OPK) is a rare, benign genetic bone condition characterized by the presence of osteosclerosis foci, and while most cases are asymptomatic, some patients experience joint pain and inflammation.
- - The case study focuses on a 33-year-old patient with concurrent ankylosing spondylitis (AS) and OPK, highlighting the complications such as severe inflammation and poor response to standard treatments, but a positive reaction to a specific TNF inhibitor.
- - The report emphasizes the importance of distinguishing OPK from serious conditions like neoplastic lesions, urging doctors to be aware of these rare cases to avoid unnecessary testing.
Molecular genetic analysis of tumor tissues is the most important step towards understanding the mechanisms of cancer development; it is also necessary for the choice of targeted therapy. The Hi-C (high-throughput chromatin conformation capture) technology can be used to detect various types of genomic variants, including balanced chromosomal rearrangements, such as inversions and translocations. We propose a modification of the Hi-C method for the analysis of chromatin contacts in formalin-fixed paraffin-embedded (FFPE) sections of tumor tissues.
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