Publications by authors named "Maxim Baten'kin"
Background/objectives: This study focuses on the development and evaluation of novel alginate-poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride (PMETAC) microcapsules for encapsulating pancreatic islets to address insulin deficiency in diabetes.
Methods: In previous research, we fabricated and characterized PMETAC microcapsules, evaluating their stability and permeability in vitro. This study further probes the capsules in vivo, focusing on the functional activity of the encapsulated islets post-transplantation, their viability extension, and the assessment of the immunoprotective, antifibrotic properties, and biostability of the capsules.
Islet allotransplantation offers a promising cell therapy for type 1 diabetes, but challenges such as limited donor availability and immunosuppression persist. Microencapsulation of islets in polymer-coated alginate microcapsules is a favored strategy for immune protection and maintaining islet viability. This study introduces Poly [2-(methacryloyloxy)ethyl]trimethylammonium chloride (PMETAC) as an innovative coating material for microcapsules.
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- The amphiphilic block copolymer was created by reacting chain transfer agents during the polymerization process of specific acrylamides, resulting in a copolymer with a conversion rate of 68% and a high molecular weight of 490,000 g/mol.
- The study focused on the colloidal chemical properties of Langmuir monolayers and Langmuir-Blodgett films formed from the synthesized block copolymer, comparing it with a functional polymer made of poly(-isopropylacrylamide).
- Results indicated that the monolayers of the block copolymer exhibited high collapse pressures regardless of subphase acidity, and their Langmuir-Blodgett films displayed a unique comb-like structure