Publications by authors named "Maxim A Sukonnikov"
The treatment of many bacterial diseases remains a significant problem due to the increasing antibiotic resistance of their infectious agents. Among others, this is related to , especially methicillin-resistant (MRSA) and . In the present article, we report on antibacterial compounds with activity against both and MRSA.
View Article and Find Full Text PDFIn this work, we present the first synthesis of dispirooxindole-β-lactams employing optimized methodology of Staudinger ketene-imine cycloaddition with N-aryl-2-oxo-pyrrolidine-3-carboxylic acids as the ketene source. Spiroconjugation of indoline-2-one with β-lactams ring is considered to be able to provide stabilization and wide scope of functionalization to resulting scaffolds. The dispipooxindoles obtained demonstrated medium cytotoxicity in the MTT test on A549, MCF7, HEK293, and VA13 cell lines, and one of the compounds demonstrated antibacterial activity against strain LPTD.
View Article and Find Full Text PDFArticle Synopsis
- 2-Oxoacids play a key role in various metabolic processes and can serve as biomarkers for certain human diseases.
- A new and improved high-performance liquid chromatography method was developed for measuring 2-oxoacids by using more stable 2,4-dinitrophenylhydrazine derivatives instead of the older phenylhydrazine ones.
- The method successfully quantified several 2-oxoacids in rat brain extracts, with a detection limit of 2 nmol/mg tissue, aiding in the identification of changes related to metabolism in mammalian tissues.