IMU Airtime Detection in Snowboard Halfpipe: U-Net Deep Learning Approach Outperforms Traditional Threshold Algorithms.

Airtime is crucial for high-rotation tricks in snowboard halfpipe performance, significantly impacting trick difficulty, the primary judging criterion. This study aims to enhance the detection of take-off and landing events using inertial measurement unit (IMU) data in conjunction with machine learning algorithms since manual video-based methods are too time-consuming. Eight elite German National Team snowboarders performed 626 halfpipe tricks, recorded by two IMUs at the lateral lower legs and a video camera.

Corrigendum: co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside , and mutations.

[This corrects the article DOI: 10.3389/fonc.2024.

co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside , and mutations.

Background: Recently, we could show that the co-mutations of + , + and + + lead to a significantly shorter median overall survival (mOS) across treatments by analyzing multiple datasets. , a tumor suppressor gene, plays a crucial role in regulating cell cycle progression. Its mutations occur in approximately 40-50% of non-small lung cancer (NSCLC).

Comparative bioinformatic analysis of KRAS, STK11 and KEAP1 (co-)mutations in non-small cell lung cancer with a special focus on KRAS G12C.

Objectives: Mutations in STK11 (STK11) and KEAP1 (KEAP1) occur frequently in non-small cell lung cancer (NSCLC) and are often co-mutated with KRAS. Several studies linked the co-occurrence of KRAS + STK11, as well as KRAS + KEAP1 to reduced response to immune checkpoint inhibitors (ICI) and even a negative impact on survival. Data focusing STK11 + KEAP1 co-mutations or the triple mutation (KRAS + STK11 + KEAP1) are scarce.

Candidate drugs associated with sensitivity of cancer cell lines with amplification or high mRNA levels.

Overexpression of the dihydrolipoamide S-succinyltransferase () is associated with poor outcome in neuroblastoma patients and triple-negative breast cancer (TNBC) and specifically with the oxidative phosphorylation (OXPHOS) pathway. Inhibitors of OXPHOS were previously suggested as a potential therapeutic strategy for a subset of patients with high-risk neuroblastoma. Here, we tested if cell lines with amplifications or high mRNA levels were associated with sensitivity to 250 drugs from the Genomics of Drug Sensitivity in Cancer (GDSC) dataset by comparing them to cell lines without these changes.

Multicompartment polymeric colloids from functional precursor Microgel: Synthesis in continuous process.

Raspberry-like poly(oligoethylene methacrylate-b-N-vinylcaprolactam)/polystyrene (POEGMA-b-PVCL/PS) patchy particles (PPs) and complex colloidal particle clusters (CCPCs) were fabricated in two-, and one-step (cascade) flow process. Surfactant-free, photo-initiated reversible addition-fragmentation transfer (RAFT) precipitation polymerization (Photo-RPP) was used to develop internally cross-linked POEGMA-b-PVCL microgels with narrow size distribution. Resulting microgel particles were then used to stabilize styrene seed droplets in water, producing raspberry-like PPs.

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines.

Purpose: A wide therapeutic repertoire has become available to oncologists including radio- and chemotherapy, small molecules and monoclonal antibodies. However, drug efficacy can be limited by genetic heterogeneity. Here, we designed a webtool that facilitates the data analysis of the in vitro drug sensitivity data on 265 approved compounds from the GDSC database in association with a plethora of genetic changes documented for 1001 cell lines in the CCLE data.

Renal Insufficiency and Medication in Nursing Home Residents. A Cross-Sectional Study (IMREN).

Background: Nursing home residents often suffer from a multiplicity of medical conditions and take many different drugs. Many drugs are eliminated via the kidneys and thus require dose adjustment in patients with renal insufficiency. This is the first study to address the prevalence of renal insufficiency among nursing home residents in Germany, and the extent to which such persons take drugs that are contraindicated or incorrectly dosed because of renal insufficiency.

[Sex-specific differences in drug utilisation in different phases of life].

The aim of the present study is to analyse sex-specific differences in drug utilisation during different phases of life using relevant diseases as examples. We used a cohort of 1.7 million subjects who were insured with the Gmünder ErsatzKasse (GEK), a German health insurance fund, for at least one day in all four quarters of 2009.

An adult case of acute biphenotypic leukemia with characteristic mixed morphology.

A case of acute biphenotypic leukemia with mixed blast morphology and combined myeloid and T-lymphoid features is reported. The leukemic cells consisted of small lymphoid hand-mirror blasts and large blasts with cytoplasmic granules and rare Auer rods. The cells expressed myeloid and immature T-lymphoid features by cytochemistry and immunophenotyping, however T cell receptor genes were in germline configuration.

The effects of incubator carbon dioxide level on turkey hatchability.

Four experiments involving CO2 level in single-stage incubators were conducted at a commercial turkey hatchery. Carbon dioxide was injected into incubators to a level of .3% during the first 10 days of incubation.