Publications by authors named "Max Waldner"
The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps.
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- The study investigates the role of Th17-associated transcription factors, specifically the Batf protein, in the development of colorectal cancer (CRC) in patients with inflammatory bowel diseases (IBDs) like ulcerative colitis and Crohn's disease.
- Researchers used genetically modified mice to show that Batf expression correlates with increased levels of IL-23 and is crucial for the regulation of both sporadic and colitis-associated colon cancer.
- The findings suggest that focusing on Batf-dependent T cells could provide new therapeutic strategies to slow down or prevent the progression of CRC in patients with IBDs.