Evaluation of redox and bioenergetics states in the liver of vitamin A-treated rats.

Vitamin A is normally stored in the mammalian liver and is physiologically released depending on the need of the organism for the vitamin. However, there is a compelling evidence showing that even the liver is affected by conditions of high vitamin A intake. Based on these previously reported findings showing negative effects of vitamin A on mammalian tissues, we have investigated the effects of a supplementation with vitamin A at clinical doses (1000-9000 IU/kg day(-1)) on some rat liver parameters.