Publications by authors named "Max Vella"
Article Synopsis
- Genetic variation at rs10830963 has been linked to type 2 diabetes, but its specific impact on insulin and glucose regulation is not fully understood.
- This study aimed to evaluate how this genetic variant affects islet function in individuals without diabetes by testing factors like glucose and insulin levels among 294 participants.
- Results indicated that carrying one or two copies of the G-allele at rs10830963 led to higher post-meal glucose and glucagon levels, suggesting it may influence diabetes risk through alterations in α-cell function.
BACKGROUNDProglucagon can be processed to glucagon-like peptide1 (GLP-1) within the islet, but its contribution to islet function in humans remains unknown. We sought to understand whether pancreatic GLP-1 alters islet function in humans and whether this is affected by type 2 diabetes.METHODSWe therefore studied individuals with and without type 2 diabetes on two occasions in random order.
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