Publications by authors named "Max Topley"
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon.
Am J Physiol Gastrointest Liver Physiol
February 2024
Article Synopsis
- Abdominal pain is a key symptom of inflammatory bowel disease (IBD), with TRP channels, particularly TRPM3, playing a role in this pain mechanism.
- In a study using mice, TRPM3 was found in 76% of certain nerve cells and showed increased activity in the presence of colitis, indicating that TRPM3 sensitivity is heightened during inflammation.
- The study suggests that targeting TRPM3 may be a potential treatment strategy for managing pain associated with IBD, especially since inhibiting TRPM3 affected nerve responses during colitis but not in healthy controls.
Background: Peripheral nerves can regenerate and restore function after injury but this process is hindered by many factors including chronic denervation, motor end-plate resorption and Schwann cell senescence. Forelimb injury models in rodents are becoming increasingly popular as they more accurately reflect the physiology and biomechanics of upper extremity nerve injuries. However several aspects of this surgical model remain poorly characterized.
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