Publications by authors named "Max T Geisinger"
Article Synopsis
- CCN2 is crucial for osteoblast differentiation and function, stimulated by TGF-β1, with a lesser-known role for AFAP1 in this process.
- AFAP1 expression in osteoblasts varies, peaking as cells proliferate and again during mineralization, and is upregulated by TGF-β1.
- The study shows that AFAP1 is necessary for Src activation and CCN2 induction in response to TGF-β1, suggesting it plays a key role in producing extracellular matrix components like collagen XIIa.
Background: Ets-1 controls osteoblast differentiation and bone development; however, its downstream mechanism of action in osteoblasts remains largely undetermined. CCN2 acts as an anabolic growth factor to regulate osteoblast differentiation and function. CCN2 is induced by TGF-β1 and acts as a mediator of TGF-β1 induced matrix production in osteoblasts; however, the molecular mechanisms that control CCN2 induction are poorly understood.
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