Publications by authors named "Max N Goder-Reiser"
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals. Analysis of 88 cell subsets and their 204 associated gene expression programs revealed extensive transcriptional and spatial remodeling across tumors.
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- The enteric nervous system (ENS) plays a crucial role in intestinal functions but has been challenging to study due to the rare and diverse nature of its cells.
- Researchers developed two innovative methods, RAISIN RNA-seq and MIRACL-seq, to analyze individual cells in the ENS of adult mice and humans, revealing a high diversity of neurons and significant gene expression changes related to age and disease.
- The study highlighted differences in neuronal profiles between the intestine regions and found that the human ENS expresses genes linked to various diseases, indicating a potential role of these neurons in health issues.
Attempts to identify physiological correlates of listening effort have mainly focused on peripheral measures (e.g. pupillometry) and auditory-evoked/event-related potentials.
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