Publications by authors named "Max Lopez"
Article Synopsis
- A study was conducted to compare the effects of low-dose (20/27 mg/m²) and high-dose (≥36 mg/m²) carfilzomib on proteasome inhibition in patients with relapsed/refractory multiple myeloma.
- Results revealed that high-dose carfilzomib significantly inhibited the β2 and β1 proteasome subunits, leading to better overall response rates and longer progression-free survival compared to low-dose treatments.
- The findings suggest that an optimal dosing of carfilzomib should be at least 36 mg/m² to enhance anti-tumor activity, while also taking into consideration individual patient tolerance.
Background: There is an incomplete understanding of the most effective approaches for motivating residents to adopt guideline-recommended practices for hospital discharges.
Objective: We evaluated internal medicine (IM) residents' exposure to educational experiences focused on facilitating hospital discharges and compared those experiences based on correlations with residents' perceived responsibility for safely transitioning patients from the hospital.
Methods: A cross-sectional, multi-center survey of IM residents at 9 US university- and community-based training programs in 2014-2015 measured exposure to 8 transitional care experiences, their perceived impact on care transitions attitudes, and the correlation between experiences and residents' perceptions of postdischarge responsibility.
Background: Medical residents are routinely entrusted with transitions of care, yet little is known about the duration or content of their perceived responsibility for patients they discharge from the hospital.
Objective: To examine the duration and content of internal medicine residents' perceived responsibility for patients they discharge from the hospital. The secondary objective was to determine whether specific individual experiences and characteristics correlate with perceived responsibility.