Publications by authors named "Max J Carlsson"
Increased intake of dietary antioxidants such as anthocyanins, which are enriched in colourful fruits, is a promising alternative to reduce the risk of degenerative diseases such as Alzheimer's Disease (AD). Since Amyloid β (Aβ) is one of the key components contributing to AD pathology, probably by reactive oxygen species (ROS) induction, this study investigated the preventive effect of anthocyanin-rich bilberry extract (BE) and its anthocyanin fraction (ACN) on ROS generation and cell toxicity. The results showed a significant and concentration-dependent decrease in neuroblastoma cell (SH-SY5Y) viability by BE or ACN, whereas no cell toxicity was observed in HeLa cells.
View Article and Find Full Text PDFArticle Synopsis
- Liver cancer is linked to viral infections, fatty liver disease, and exposure to carcinogens like aflatoxins and certain plant toxins, including methyleugenol (ME), found in various foods and cosmetics.
- Upon metabolism of ME, DNA damage occurs, primarily through the formation of a harmful DNA adduct, N-MIE-dG, which is influenced by the expression of the enzyme SULT1A1.
- The resultant DNA damage activates the ATR pathway, triggering cell cycle checkpoints and leading to cell death, particularly through pathways involving the p53 protein, highlighting its significance in mediating the response to ME-induced damage.
Primary hepatocytes are the gold standard in pharmaco- and toxicokinetic studies during preclinical development of drug candidates. Such cells are a valuable tool to identify potential hepatotoxicity, an important adverse drug reaction. Primary hepatocytes can be obtained not only from wild-type mice but also from genetically engineered knockout mouse strains.
View Article and Find Full Text PDF