Transtympanic delivery of VO nanowires with a tympanic-membrane penetrating peptide.

Otitis media is a prevalent pediatric condition. Local delivery of antimicrobial agents to treat otitis media is hindered by the low permeability of the stratum corneum layer in the tympanic membrane. While nanozymes, often inorganic nanoparticles, have been developed to cure otitis media in an antibiotic-free manner in a chinchilla animal model, the tympanic membrane creates an impenetrable barrier that prevents the local and non-invasive delivery of nanozymes.

On-Demand Synthesis of Antiseptics at the Site of Infection for Treatment of Otitis Media.

Otitis media (OM) is the main reason for pediatric antibiotic prescriptions. The current treatment mandates a rigorous regimen of multidose antibiotics over 5-10 days. The systemic antibiotic exposure and often prematurely terminated treatment due to the challenge of drug administration to young patients are believed to breed antibiotic resistance.

Haloperoxidase-mimicking CeO nanorods for the deactivation of human coronavirus OC43.

Despite the excellent antibacterial and antifouling effects of haloperoxidase (HPO)-mimicking CeO nanorods, their antiviral efficiency has not been explored. Herein, we designed and synthesized CeO nanorods with varying aspect ratios the hydrothermal method. CeO nanorods catalysed the oxidative bromination of Br and HO to HOBr, the kinetics of which were studied systematically using a phenol red assay.