Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption.

Recent concepts suggest that both Plasmodium falciparum factors and coagulation contribute to endothelial activation and dysfunction in pediatric cerebral malaria (CM) pathology. However, there is still limited understanding of how these complex inflammatory stimuli are integrated by brain endothelial cells. In this study, we examined how mature-stage P.

Unveiling the double-well energy landscape in a ferroelectric layer.

The properties of ferroelectric materials, which were discovered almost a century ago, have led to a huge range of applications, such as digital information storage, pyroelectric energy conversion and neuromorphic computing. Recently, it was shown that ferroelectrics can have negative capacitance, which could improve the energy efficiency of conventional electronics beyond fundamental limits. In Landau-Ginzburg-Devonshire theory, this negative capacitance is directly related to the double-well shape of the ferroelectric polarization-energy landscape, which was thought for more than 70 years to be inaccessible to experiments.

The impact of Playworks on students' physical activity during recess: findings from a randomized controlled trial.

Objective: To evaluate the impact of Playworks on students' physical activity during recess.

Method: Twenty-seven elementary schools from six U.S.

Estimated Distributions of Usual Physical Activity during Recess.

Purpose: This study aimed to estimate distributions of usual physical activity during recess in schools in low-income areas using measurement error models and to compare model-adjusted distributions to unadjusted distributions based on a single day of measurement.

Methods: A randomized study of the Playworks program was conducted in 29 schools from six U.S.