Publications by authors named "Max A Verbiest"
Article Synopsis
- STR mutations are common in colorectal cancer (CRC), particularly in tumors with microsatellite instability (MSI), yet their impact on gene regulation is not well understood.
- Researchers combined STR mutation data with clinical and gene expression information to investigate how these mutations affect gene regulation in CRC.
- They identified a set of 1244 expression STRs (eSTRs) linked to gene expression levels, with specific eSTRs affecting cancer-related genes, highlighting a potential new avenue for cancer treatment approaches.
The dopamine transporter gene, , has received substantial attention in genetic association studies of various phenotypes. Although some variable number tandem repeats (VNTRs) present in have been tested in genetic association studies, results have not been consistent. VNTRs in that have not been examined genetically were characterized.
View Article and Find Full Text PDFShort tandem repeats (STRs) are abundant in genomic sequences and are known for comparatively high mutation rates; STRs therefore are thought to be a potent source of genetic diversity. In protein-coding sequences STRs primarily encode disorder-promoting amino acids and are often located in intrinsically disordered regions (IDRs). STRs are frequently studied in the scope of microsatellite instability (MSI) in cancer, with little focus on the connection between protein STRs and IDRs.
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