Publications by authors named "Mavinahalli J"
Article Synopsis
- Researchers focused on creating reversible and selective BTK inhibitors, using 7H-pyrrolo[2,3-d]pyrimidine and 1H-pyrrolo[2,3-b]pyridine as core structures.
- They found two promising lead compounds, 11 and 13, that showed strong BTK inhibition in various cell tests and high selectivity among 50 diverse kinases.
- These compounds also displayed good pharmacokinetics in mice and had positive effects in a mouse model for arthritis.
Purpose: Neurotrophin-4 protein (NT-4) plays a role in the protection of retinal ganglion cells by activating tyrosine kinase B (TrkB) receptors. A recent study identified mutations within the neurotrophin-4 (NTF4) gene to account for 1.7% of primary open-angle glaucoma (POAG) in Europeans.
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- Understanding the mechanisms by which antimicrobial peptides interact with membranes is essential for designing effective synthetic analogues, particularly defensins, which play a vital role in innate immunity.
- This study involved synthesizing eight analogues of hBD3 and a covalent dimer, identifying that certain analogues like Y2 and V2 exhibit strong antibacterial activity against Gram-negative bacteria, specifically Pseudomonas aeruginosa.
- Cytotoxicity tests indicated that these peptides are non-toxic to human cells at high concentrations, and fluorescence correlation spectroscopy showed that the dimer V2-dimer is particularly effective in causing membrane disruption in bacterial mimics, making it the most potent antimicrobial candidate tested.
The N terminal transactivation domain of p53 is regulated by ligases and coactivator proteins. The functional conformation of this region appears to be an alpha helix which is necessary for its appropriate interactions with several proteins including MDM2 and p300. Folding simulation studies have been carried out to examine the propensity and stability of this region and are used to understand the differences between the family members with the ease of helix formation following the order p53 > p73 > p63.
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