Acceptability and Determinants of Opportunistic Screening for Breast Cancer in Indian Women.

Background: Screening for breast cancer has been effective in decreasing mortality. Mammography is not readily available in resource-limited countries like India. Annual clinical breast examination has been demonstrated to be as effective as biennial mammography in reducing mortality with much less cost.

Bacopa monnieri Extract Diminish Hypoxia-Induced Anxiety by Regulating HIF-1α Signaling and Enhancing the Antioxidant Defense System in Hippocampus.

Hypoxia is a significant stressor, and stabilized hypoxia-inducible factor-1α (HIF-1α) regulates the expression of numerous genes, leading to various biochemical, molecular, physiological and genomic changes. The body's oxygen-sensing system activates gene expression to protect brain tissues from hypoxia. Gamma-aminobutyric acid, an inhibitory neurotransmitter, regulates brain excitability during hypoxia through the activation of HIF-1 α.

Transition Metal Complexes Containing Selenium Ligands for Catalytic Reduction, Oxidation, and Hydrofunctionalization Reactions.

Transition metal-mediated catalytic reduction, oxidation, and hydrofunctionalization reactions are important organic reactions and are considered highly atom-economical. Owing to their unique properties, selenium ligated several transition metals-based complexes have been reported for several catalytic applications. This review presents the synthesis of various selenium-supported transition metal complexes and their catalytic applications in reduction, oxidation, N-alkylation of amines, and hydrofunctionalization reactions.

Nanoencapsulated Essential Oils for Post-Harvest Preservation of Stored Cereals: A Review.

Cereal grains are frequently attacked by microorganisms and insects during storage and processing, which negatively affects their quality, safety, and market value. Therefore, protecting stored grains from microbial contamination is crucial for food industries, farmers, public health associations, and environmental agencies. Due to the negative impact of synthetic gray chemicals, antimicrobial plant-based essential oils (EOs) can serve as alternative, safer, environmentally friendly preservatives that can prolong the shelf life of cereals.

Edible Berries-An Update on Nutritional Composition and Health Benefits-Part II.

Purpose Of Review: Berries are a great source of fiber, polyunsaturated fatty acids, and beneficial secondary metabolites (polyphenols). Various phytochemicals present in berries (glycosidic-linked flavonoids, anthocyanins, etc.) provide potential health benefits to consumers.

Edible Berries- An Update on Nutritional Composition and Health Benefits- Part III.

Purpose Of Review: The diverse polyphenolic components present in these berries are responsible for their functional properties in human health. Hence, there is an increasing demand for research in berry bioactive components to understand the mechanism of action in alleviating and preventing diseases. Therefore, in this last part-III of the review series, mulberry, raspberry, salmonberry, Saskatoonberry, and strawberry are discussed in terms of their bioactive components and corresponding substantial health benefits.

Edible Berries- An Update on Nutritional Composition and Health Benefits-Part I.

Purpose Of Review: This review delves comprehensively into the nutritional profiles and diverse biological activities of different berries. So far 19 different types of berries have been identified for human consumption and studied for their nutritional and biological activities. Among them, acai berry, blueberry, blackberry, black currant, boysenberry, and bilberry have been summarized in this review (Part I).

Structure of the Complex of Lactoperoxidase With Nitric Oxide at 1.95 Å Resolution.

Lactoperoxidase (LPO) is a heme-containing mammalian enzyme that is found in the extracellular fluids of animals including plasma, saliva, airway epithelial and nasal lining fluids, milk, tears, and gastric juices. LPO uses hydrogen peroxide (HO) to convert substrates into oxidized products. Previous structural studies have shown that HO, CO, and CN are bound to LPO at the distal heme cavity by coordinating with heme iron.

A Challenging Case of Miliary Tuberculosis in Pregnancy.

Miliary tuberculosis (TB) is an uncommon yet severe condition that can pose substantial risks to pregnant women and their unborn child. This case study describes a 22-year-old pregnant female at 23 weeks of gestation presented with breathlessness, fever accompanied by chills, dry cough, and loss of appetite. With no significant comorbidities, her initial symptoms were inconclusive, leading to her initial diagnosis as a case of pyrexia of unknown origin.

Temporal mechanisms underlying visual processing bias in peri-hand space.

The immediate space surrounding the hands has often been termed the peri-hand space (PHS), and is characterized by a smaller reaction time (RT), better detection, and enhanced accuracy for stimuli presented in this space, relative to those stimuli presented beyond this space. Such behavioral changes have been explained in terms of a biased allocation of cognitive resources such as perception, attention, and memory, for the efficient processing of information presented in the PHS. However, in two experiments, the current study shows that these cognitive biases seem to have an underlying temporal basis.

Extended-spectrum β - lactamase inhibitory potential of : an and computational studies.

Extended-spectrum β-lactamases (ESBL) producing enterobacteriales are a major global health concern since they often result in the ineffectiveness of empirical antibiotic therapy with β-lactams. This study aims to identify potential medicinal plants that can inhibit β-lactamase and subsequently enhance the activity of the β-lactams against resistant bacterial strains. A synergistic study of extract exhibited good synergistic activity against a CTX-M-producing organism, which was confirmed using an agar-based diffusion bioassay method.

Mechanical, Thermal, and Morphological Analysis of Himalayan Agave Fiber/GO Coated Fly Ash Hybrid Polypropylene Composites.

Composites containing two different types of reinforcements offer a wide range of possibilities and synergistic properties. This study investigates the hybridization effect of chemically active fly ash (FA) (5 wt %) on the composites made from alkali (1 wt %) - APTES silane (2 wt %) treated Himalayan agave fibers (HAF) (25 wt %) and polypropylene (PP). Prior to FA activation, the planetary ball mill was used to suitably reduce the particle size of the FA with was confirmed by the dynamic light scattering approach.

Molybdenum trioxide as a newer diversified economic catalyst for the transformation of nitroarenes to arylamine and 5-substituted-1-tetrazole.

The present work has developed a straightforward, gentle, and effective approach for synthesizing arylamines and 5-substituted-1-tetrazole derivatives, and among the two tested catalysts, molybdenum trioxide (MoO) proved to be highly effective. The selective hydrogenation of nitroarenes to arylamines presents a significant challenge due to the complex reaction mechanism and the competitive hydrogenation of other reducible functional groups. It facilitated the transfer hydrogenation of nitrobenzene using hydrazine hydrate-produced amino compounds and enabled the [3 + 2] cycloaddition of sodium azide with aromatic nitriles to yield 5-substituted-1-tetrazoles.

Budd-Chiari Syndrome Associated With Autoimmune Hemolytic Anemia, Immune Thrombocytopenic Purpura, and Lupus Nephritis: A Case Report.

Budd-Chiari syndrome (BCS) is a scarce but severe condition characterized by the obstruction of the hepatic veins, liver congestion, and consequent damage. This series brings up one unusual presentation of BCS associated with autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), and lupus nephritis (LN), which collectively complicate the clinical scenario. This is a 19-year-old woman who was admitted for abdominal pain, hepatomegaly, ascites, and jaundice.

Sisal Fiber Reinforced and Cenosphere Hybridized Polypropylene-SEBS Composite: An Insight into Crystallographic, Dynamic Mechanical and Rheological Behavior.

The current study attempts to explore the crystallographic, rheological and, dynamic mechanical properties of the submicron-treated cenosphere (t- CSF) particles and sisal fiber (SF) reinforced Styrene-(Ethylene-Butylene)-Styrene (SEBS) toughened PP hybrid composites. Moreover, the composites reinforced with 25 wt.% of SF and 5 wt.

Discovering New QTNs and Candidate Genes Associated with Rice-Grain-Related Traits within a Collection of Northeast Core Set and Rice Landraces.

Grain-related traits are pivotal in rice cultivation, influencing yield and consumer preference. The complex inheritance of these traits, involving multiple alleles contributing to their expression, poses challenges in breeding. To address these challenges, a multi-locus genome-wide association study (ML-GWAS) utilizing 35,286 high-quality single-nucleotide polymorphisms (SNPs) was conducted.

Neuroinflammation and acetylcholinesterase inhibition potentials of acyclic monoterpenoids isolated from (Nees ex Steud.) Will. Watson.

(Nees ex Steud.) Will. Watson (Poaceae) is a promising aromatic plant distributed in the Himalayas.

Structural Characterization, Spectroscopic Profile, Molecular Docking, ADMET Properties, Molecular Dynamics Simulation Studies, and Molecular Mechanics Generalized Born Surface Area Analysis of 5-(Adamantan-1-yl)-4-butyl-2,4-dihydro-3-1,2,4-triazole-3-thione as a Potential COX Inhibitor.

Employing a synergistic combination of theoretical density functional theory (DFT) and experimental techniques, we conducted a comprehensive analysis elucidating the structural and pharmacological attributes of 5-(adamantan-1-yl)-4-butyl-2,4-dihydro-3-1,2,4-triazole-3-thione (5A4BT) as a potent COX inhibitor. The X-ray crystallographic data of 5A4BT showed the pivotal role played by weak interactions, notably π-π and C-H-π interactions, alongside hydrogen bonding, in orchestrating the intricate supramolecular architectures within the crystalline lattice. A quantitative analysis of the arrangement of the crystal structure, as well as both inter- and intramolecular interactions, was conducted using Hirshfeld surfaces and 2D fingerprint plots.