Publications by authors named "Maury P"
Article Synopsis
- Arrhythmic risk stratification in Brugada syndrome is challenging, and this study aimed to evaluate the predictive value of automatically measured ECG parameters from digitized paper ECGs.
- In a multicenter study involving 301 patients, two ECG parameters (QRS prolongation in lead V1 and S duration on DI) were found to independently predict major cardiac events.
- The study concluded that automatic ECG analysis could effectively assess risk in Brugada syndrome patients by confirming known parameters and identifying new ones.
Article Synopsis
- Left ventricular assist devices (LVADs) are commonly used to treat advanced heart failure, improving survival but leading to high rates of arrhythmias (20-50%) within a year after implantation.
- Arrhythmias in these patients increase the risk of complications, such as additional shocks from implantable defibrillators and potential worsening of right ventricular failure, highlighting the need for tailored management strategies.
- Effective treatment for these arrhythmias may involve specialized approaches like catheter ablation, though unique challenges exist in accessing arrhythmogenic areas after LVAD surgery, making pre-implantation procedures potentially beneficial.
Background And Aims: Prophylactic implantable cardioverter-defibrillators (ICDs) are not recommended until left ventricular ejection fraction (LVEF) has been reassessed 40 to 90 days after an acute myocardial infarction. In the current therapeutic era, the prognosis of sustained ventricular arrhythmias (VAs) occurring during this early post-infarction phase (i.e.
View Article and Find Full Text PDFCombination of nanoagents with radiations has opened up new perspectives in cancer treatment, improving both tumor diagnosis and therapeutic index. This work presents the first investigation of an innovative strategy that combines porous metal-organic frameworks (nanoMOFs) loaded with the anti-cancer drug Gemcitabine monophosphate (GemMP) and particle therapy-a globally emerging technique that offers more precise radiation targeting and enhanced biological efficacy compared to conventional radiotherapy. This radiochemotherapy has been confronted with two major obstacles limiting the efficacy of therapeutics when tested in vivo: (i) the presence of hypoxia, one of the most important causes for radiotherapy failure and (ii) the presence of a microenvironment, main biological barrier to the direct penetration of nanoparticles into cancer cells.
View Article and Find Full Text PDFArticle Synopsis
- SCN5A gene variants are linked to various cardiac electrical disorders, but they can also result in complex phenotypes like overlap syndromes, which haven't been thoroughly studied.
- The study analyzed DNA from over 13,500 patients with a focus on those carrying pathogenic SCN5A variants, finding that most were tied to well-defined conditions like Brugada syndrome and long QT syndrome.
- About 19% of the variants were associated with complex phenotypes, and only a small number (8 out of 9,960 patients) showed a potential link to dilated cardiomyopathies (DCM), suggesting it's a rare association.
Aim: The diagnosis of hypertrophic cardiomyopathy (HCM) with moderate hypertrophy is challenging. Hypertensive heart disease (HHD) is the most common differential diagnosis that mimics the LVH of HCM. The aim of this study was to compare the QRS duration in HCM and HHD to create a novel diagnostic tool to identify primary HCM.
View Article and Find Full Text PDFArticle Synopsis
- Pulsed field ablation (PFA) is a new method for treating atrial fibrillation (AF) that focuses on ablating heart tissue while minimizing harm to nearby structures.
- In the MANIFEST-17K study, data from 106 centers involved 17,642 patients and showed no serious complications like esophageal damage, with only a 1% major complication rate.
- The results suggest that PFA has a strong safety profile and may change how AF is treated, compared to traditional thermal ablation methods.
Background: Idiopathic ventricular fibrillation (IVF) can be associated with undetected distinct conditions such as microstructural cardiomyopathic alterations (MiCM) or Purkinje (Purk) activities with structurally normal hearts.
Objectives: This study sought to evaluate the characteristics of recurrent VF recorded on implantable defibrillator electrograms, associated with these substrates.
Methods: This was a multicenter collaboration study.
Article Synopsis
- AGuIX nanoparticles are gadolinium-based agents that serve as both MRI contrast agents and enhance the effectiveness of X-ray radiation therapy for cancer treatment.
- A phase I trial tested the safety and optimal dosage of AGuIX in combination with conventional therapies for 12 patients with advanced cervical cancer, showing good tolerability and no severe side effects.
- The treatment resulted in complete remission of the primary tumors in all but one patient, highlighting the potential of these nanoparticles to improve the precision of tumor targeting and enhance radiotherapy outcomes.
Background: Atrial fibrillation (AF) and heart failure (HF) coexist, increasing morbidity and mortality. Studies have demonstrated improved outcomes following AF ablation in HF patients with reduced ejection fraction (EF).
Objective: To assess the outcomes of pulsed-field ablation (PFA) in HF.
Background: Atrial fibrillation (AF) and heart failure (HF) coexist, increasing morbidity and mortality. Studies have demonstrated improved outcomes following AF ablation in HF patients with reduced ejection fraction (EF).
Objective: This study sought to assess the outcomes of pulsed field ablation (PFA) in HF.
Article Synopsis
- The BEAT PAROX-AF trial is a European study comparing pulsed field ablation (PFA) with radiofrequency (RF) ablation for treating drug-resistant paroxysmal atrial fibrillation (AF), focusing on efficacy and safety.
- A total of 292 participants were randomly assigned to either PFA or RF using specific protocols to measure outcomes such as the recurrence of atrial arrhythmia and serious adverse events.
- The study began in December 2021 and will conclude recruitment in January 2024, with results expected to be published in mid-2025, aiming to improve treatment strategies for patients with paroxysmal AF.
. Severe radiation-induced lymphopenia occurs in 40% of patients treated for primary brain tumors and is an independent risk factor of poor survival outcomes. We developed anframework that estimates the radiation doses received by lymphocytes during volumetric modulated arc therapy brain irradiation.
View Article and Find Full Text PDFArticle Synopsis
- Electrical storm (ES) is a serious condition characterized by repeated episodes of dangerous heart rhythms (ventricular arrhythmias) occurring within 24 hours, requiring medical intervention.
- It mainly affects patients with existing heart issues or those with implantable cardioverter-defibrillators (ICDs), and it poses significant health risks despite advanced treatments.
- The increasing number of older patients with heart conditions and ICDs suggests that the incidence of ES is likely to rise, prompting the need for comprehensive management strategies and a multi-disciplinary approach.
Background: Atrial arrhythmias (AA) commonly affect patients with cardiac amyloidosis (CA) and are a contributing risk factor for the development of heart failure (HF). This study sought to investigate the long-term efficacy and impact of catheter ablation on HF progression in patients with CA and AA.
Methods: Thirty-one patients with CA and AA undergoing catheter ablation were retrospectively included (transthyretin-ATTR CA 61% and light chain-AL CA 39%).
Article Synopsis
- The study investigates the out-of-field dose delivered during external photon beam radiation therapy, as it may lead to a higher risk of second cancers and affect immune system efficiency in radio-immunotherapy treatments.
- Traditional methods for estimating out-of-field doses are complex and not suitable for clinical use, prompting the exploration of deep learning techniques for more effective dose map prediction.
- A 3D U-Net model, trained on data from 3,151 pediatric patients, demonstrated promising results in estimating out-of-field doses, achieving low error rates in both training and validation, indicating potential for clinical application.
Background: Pulsed field ablation has recently emerged as an interesting non-thermal energy for atrial fibrillation ablation. At a time of rapid spread of this technology, there is still a lack of prospective real-life data.
Aim: To describe multicentre prospective safety and 1-year efficacy data in three of the first French centres to use pulsed field ablation.
Article Synopsis
- The study looks into how many sudden deaths happen in France and finds that estimates vary a lot based on different methods used.
- In Haute-Garonne, there are about 26 resuscitated sudden deaths and 145 autopsies each year, which helps give a bigger picture for all of France.
- The researchers think the actual number of sudden deaths might be higher or lower than what was previously thought, and they suggest more careful studies should be done to understand this better.