Publications by authors named "Mauro Poggio"
Article Synopsis
- Immune checkpoint inhibition (ICI) has changed cancer therapy, but only some patients experience long-term benefits, highlighting the need for new targets and treatments.* -
- Researchers utilized the 23andMe database to find a genetic signature linking variations that affect both cancer and immune disease risks, discovering key genes like CD200 and CD200R1.* -
- They developed a high-affinity antibody (23ME-00610) that inhibits the CD200:CD200R1 interaction, which enhances T-cell activity and reduces tumor growth in mouse models of melanoma.*
PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby suppressing their activity. Antibody blockade of PD-L1 can activate an anti-tumor immune response leading to durable remissions in a subset of cancer patients. Here, we describe an alternative mechanism of PD-L1 activity involving its secretion in tumor-derived exosomes.
View Article and Find Full Text PDFCancer cells develop mechanisms to escape immunosurveillance, among which modulating the expression of immune suppressive messenger RNAs is most well-documented. However, how this is molecularly achieved remains largely unresolved. Here, we develop an in vivo mouse model of liver cancer to study oncogene cooperation in immunosurveillance.
View Article and Find Full Text PDFWe apply the time-frequency analysis to the endocavitarian signal of patients suffering from paroxysmal atrial fibrillation. The time-frequency spectrum reveals the components of the endocavitarian signal. These components are located in the regions of the time-frequency domain that differ for in-rhythm and in-atrial fibrillation signals.
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