Publications by authors named "Mauro Melpignano"
Article Synopsis
- The study investigates the role of mesenteric lymph node (MLN) involvement in the prognosis of advanced ovarian cancer (AOC) patients who underwent surgeries from 2007 to 2017.
- Out of 83 patients analyzed, 51.8% had positive MLN involvement, which correlated significantly with involvement in pelvic and aortic lymph nodes and deeper bowel infiltration.
- The findings suggest that negative MLN status is associated with better overall and disease-free survival, highlighting the importance of radical bowel resection during surgery for AOC with bowel involvement.
Article Synopsis
- The study aimed to investigate the outcomes of pelvic lymphadenectomy in early-stage endometrial cancer, focusing on how age and body mass index affect survival rates.
- Analyses showed that patients over 65 years have significantly lower cancer-specific survival (CSS) and overall survival (OS) rates compared to younger patients, regardless of lymphadenectomy status.
- The results indicate that older age, higher tumor grade, and higher stage are linked to worse prognoses, and obesity also contributes negatively to outcomes in older patients.
Article Synopsis
- A phase 2 study evaluated the safety and efficacy of neoadjuvant chemotherapy using irinotecan and cisplatin in patients with locally advanced cervical cancer at 13 centers in Italy from 2000 to 2003.
- Out of 71 patients analyzed, the overall response rate was 73.2%, with 12.7% achieving complete responses and 60.6% showing partial responses.
- Despite some serious adverse events, the treatment showed a promising overall survival rate of 87% at 4 years, suggesting potential for further investigation in a phase 3 study.
Background: Median laparotomy is the most common approach to the abdominopelvic cavity in patients with gynaecological tumours.
Aims: The primary endpoint of the study was to evaluate the onset of incisional hernia. The secondary endpoint was to evaluate the onset of infection, wound dehiscence, wound infection, and scar pain during the post-operative period.
Article Synopsis
- Pelvic lymph nodes often harbor tumors in early-stage endometrial cancer, and a randomized trial was conducted to examine if adding pelvic systematic lymphadenectomy to standard surgery improves patient survival outcomes.
- The study included 514 patients with early-stage endometrial cancer, randomly assigned to either undergo pelvic lymphadenectomy (264 patients) or not (250 patients), with various clinical data collected post-surgery.
- Results showed that lymphadenectomy significantly increased the number of lymph nodes removed and improved surgical staging by detecting more metastases, but it also led to higher rates of postoperative complications.
Aim: In this article, for the first time, we investigate the presence of human papillomavirus (HPV) DNA in ovarian epithelial neoplasms from a group of 71 Italian women. The follow ups of the patients with or without HPV DNA were also considered to evaluate whether HPV DNA in these tumors could be an indicator of prognosis.
Methods: HPV DNA was evaluated by polymerase chain reaction (PCR).
Article Synopsis
- The study focuses on evaluating the effectiveness of ultrasonography and gross examination in detecting myometrial infiltration and tumor differentiation in patients with stage I endometrial cancer.
- Researchers analyzed data from 75 patients, finding 60% concordance between biopsy results and final histology, with ultrasonography showing a diagnostic accuracy of 73% and gross examination at 82.6%.
- The findings suggest that these non-invasive methods can reliably predict myometrial invasion in low-risk patients, potentially allowing them to avoid unnecessary lymphadenectomy.
This investigation is the first to evaluate simultaneously human papilloma virus (HPV) status, p16(INK4a), and p53 immunoreactivity in epithelial ovarian neoplasms. The results were analyzed and correlated with histological type, histological grade, and survival of patients. Subtypes considered are papillary serous and mucinous.
View Article and Find Full Text PDFIn this paper, we report 2 new cases of villoglandular papillary adenocarcinoma (VGPA) of the cervix, a rare, well-differentiated form of cervical adenocarcinoma. Both patients were without medical complications or history of oral contraceptive use and were nonsmokers. Extended hysterectomy was performed in both cases.
View Article and Find Full Text PDFObjectives: We analyzed clinical data and pathological features of six cases of malignant endometrial polyps, to compare these with other examples reported in literature and to define the features of endometrial cancer arising in polyps. Moreover, to clarify the mechanisms of carcinogenesis in malignant endometrial polyps we examined the expression of cyclooxygenase-2 (COX-2), P53 and Ki 67 and their relationships with clinicopathologic characteristics.
Methods: The surgical pathology files of the Pathology Department of Parma University were searched for cases of endometrial polyps with nests of endometrial carcinomas, from the years 2002-2005.
We report a case of a haematoma of the Retzius space after spontaneous uncomplicated delivery. In the postpartum period, the patient complained of urinary retention and pain in the hypogastric region radiating to her left hip and leg. The ultrasound examination showed the presence of 160 x 100 x 80 mm confluent solid and liquid areas with peripheral vascularization.
View Article and Find Full Text PDFIn this paper, we report a new case of metastatic endometrial carcinoma to the vulva and describe the clinical and pathological features. We reviewed the literature to determine the frequency and to evaluate the prognostic significance of this rare disease. Moreover, we discuss the criteria for the differential diagnosis of endometrial carcinoma metastatic to the vulva, the primary vulvar adenocarcinomas, and other metastatic adenocarcinomas.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses two cases of endometrial microglandular adenocarcinoma, a rare type of cancer that can appear similar to other benign conditions of the cervix and endometrium.
- It highlights the importance of proper diagnosis using clinical data, morphological features, and immunohistochemical markers.
- The study also found no association between the cancer and human papilloma virus (HPV) infection, suggesting that other factors like aging or hormonal changes may play a role in its development.
Endometrial cancer in patients with preoperative diagnosis of atypical endometrial hyperplasia.
Eur J Obstet Gynecol Reprod Biol
September 2005
Objective: Atypical endometrial hyperplasia (AEH) has been associated with the presence of concomitant endometrial carcinoma (EC). The aim of this study is to examine the frequency of coexisting endometrial carcinoma when atypical endometrium hyperplasia was found upon biopsy. We also evaluated the influence of preoperative diagnostic techniques (pipelle and dilation and curettage (D&C)), and the value of transvaginal ultrasound in detecting unexpected tumor invasion.
View Article and Find Full Text PDFBackground And Aim Of The Work: Our purpose was to evaluate the efficacy of a single-dose of MTX for ectopic pregnancy treatment in a sample of patients carefully selected according to strict inclusion criteria.
Methods: 11 patients that matched the inclusion criteria were enrolled.
Results: Beta-hCG at diagnosis averaged 1349 mIU/ml out of the 11 treated patients, 10 (90%) received a single dose of MTX and had a time of EP resolution averaging 27.
Purpose: To analyze the effect of different doses of paclitaxel with fixed doses of carboplatin in the treatment of ovarian cancer.
Patients And Methods: Patients with histologically confirmed epithelial ovarian cancer, International Federation of Gynecology and Obstetrics stages IIB to IV, were eligible for this randomized, multicenter study. Women were randomly assigned to treatment with (1) carboplatin at the dose (in milligrams) corresponding to the following formula: target area under the free carboplatin plasma concentration versus time curve (AUC) = 6 x (glomerular filtration rate + 25) mg/m(2) (AUC6) plus paclitaxel 175 mg/m(2) for six cycles every 21 days or (2) carboplatin AUC6 plus paclitaxel 225 mg/m(2) for six cycles every 21 days.
We report a rare case of small-cell carcinoma of the uterine corpus. To our knowledge, this is the first radiological report. Computed tomography (CT) demonstrates a hypodense lesion within the endometrial cavity with nonhomogeneous contrast enhancement.
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