Publications by authors named "Mauro Felippe F Mediano"
Background: The mechanisms that determine the progression to cardiac or digestive forms of chronic Chagas disease (CD) are still unclear. We assessed the association between blood group antigens ABO, Rh, Kell, Kidd, Duffy and MNS, and chronic CD clinical forms.
Methods: Patients were included consecutively between March 2013 and April 2016.
Article Synopsis
- A study found that a positive T. cruzi PCR test in chronic Chagas disease patients is linked to poorer health outcomes.
- The research analyzed data from 333 patients, revealing a 41.1% positivity rate for the PCR test, with significant associations identified for diabetes, right bundle branch block, and past trypanocidal treatment.
- Notably, having a history of trypanocidal treatment significantly lowered the chances of a positive PCR result, highlighting its protective benefits.
Two-dimensional strain derived parameters provide independent predictors of progression to Chagas cardiomyopathy and mortality in patients with Chagas disease.
Int J Cardiol Heart Vasc
February 2022
Background: Patients with chronic Chagas disease (CD) cardiomyopathy have a high mortality. We evaluated if two-dimensional (2D) strain () parameters provide independent predictors of progression to CD cardiomyopathy and all-cause mortality.
Methods: A total of 408 patients with chronic CD (58.
Chagas heart disease (CHD) affects approximately 30% of patients chronically infected with the protozoa . CHD is classified into four stages of increasing severity according to electrocardiographic, echocardiographic, and clinical criteria. CHD presents with a myriad of clinical manifestations, but its main complications are sudden cardiac death, heart failure, and stroke.
View Article and Find Full Text PDFBackground: Atrial fibrillation (AF) carries ominous consequences in patients with Chagas disease. The aim of this study was to determine whether left atrial (LA) volume and function assessed using three-dimensional echocardiographic (3DE) imaging and two-dimensional speckle-tracking echocardiographic deformation analysis of strain (ε) could predict new-onset AF in patients with Chagas disease.
Methods: A total of 392 adult patients with chronic Chagas disease (59% women; mean age, 53 ± 11 years) who underwent echocardiography were consecutively enrolled in this prospective longitudinal study.
The impact of exercise frequency upon microvascular endothelium function and oxidative stress among patients with coronary artery disease.
Clin Physiol Funct Imaging
September 2018
Purpose: This study compared the effects of low and high weekly exercise frequencies on microvascular endothelium function and oxidative stress among patients with coronary artery disease.
Methods: Thirty-four male patients completed a 6-month cardiac rehabilitation programme, from which 23 performed exercise with a high frequency (HF) and 11 with a low frequency (LF). Systemic microvascular blood flow, maximal aerobic capacity, blood lipids, oxidative stress and anthropometric data were assessed prior to and after the cardiac rehabilitation programme.