Publications by authors named "Mauro Calicchio"
Article Synopsis
- Insulin-like peptide 3 (INSL3) is a key biomarker for Leydig cells in vertebrate testes and plays a crucial role in sperm production by binding to the RXFP2 receptor.
- The study examines the expression of the Insl3 gene and its precursor in both reproductive and non-reproductive tissues, finding low levels of INSL3 in Leydig and germ cells throughout testis development.
- Results indicate that INSL3 has both autocrine and paracrine functions in the testis, and highlight a conserved ligand-receptor interaction mechanism across various vertebrate species.
