A heuristic underlies the search for relief in Drosophila melanogaster.

Humans rely on multiple types of sensory information to make decisions, and strategies that shorten decision-making time by taking into account fewer but essential elements of information are preferred to strategies that require complex analyses. Such shortcuts to decision making are known as heuristics. The identification of heuristic principles in species phylogenetically distant to humans would shed light on the evolutionary origin of speed-accuracy trade-offs and offer the possibility for investigating the brain representations of such trade-offs, urgency and uncertainty.

Students' mental health problems before, during, and after COVID-19 lockdown in Italy.

The lockdown due to the coronavirus pandemic may have exacerbated mental health problems. To what degree mental health may be affected by social isolation is still poorly known. We collected prospective data on students' mental health in two instances: (i) in October and December 2019, and (ii) 6 months later, in April 2020 amidst the COVID-19 lockdown in Italy and in mid-May/June 2020, after the lifting of lockdown.

Searching for relief: Drosophila melanogaster navigation in a virtual bitter maze.

Animals use relief-based place learning to pinpoint a specific location where noxious stimuli are diminished or abolished. Here we show how the optogenetically-induced activation of bitter-sensing neurons in Drosophila melanogaster elicits pain-like behavioural responses and stimulates the search for a place where this activation is relieved. Under this "virtual" stimulation paradigm it would be feasible to test relief learning several times throughout an animal's lifespan, without the potentially damaging effects which may result from the repeated administration of "real" heat or electrical shock.

Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back.

Clinical and research studies have suggested a link between Parkinson's disease (PD) and alterations in the circadian clock. may represent a useful model to study the relationship between the circadian clock and PD. Apart from the conservation of many genes, cellular mechanisms, signaling pathways, and neuronal processes, shows an organized central nervous system and well-characterized complex behavioral phenotypes.

Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?

There is evidence of a link between the circadian system and psychiatric diseases. Studies in humans and mammals suggest that environmental and/or genetic disruption of the circadian system leads to an increased liability to psychiatric disease. Disruption of clock genes and/or the clock network might be related to the etiology of these pathologies; also, some genes, known for their circadian clock functions, might be associated to mental illnesses through clock-independent pleiotropy.