Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of WNT/signaling, mitochondrial activity, and stem cells maintenance.

Background: Mechanisms involved in hair metabolism are diverse, and the availability of ingredients that normalize dysfunctions or mitigate the effects of extrinsic stress suffered daily is greatly desired by consumers to improve the aesthetic appearance of hair.

Aims: In this work, we carried out a preclinical exploratory approach to evaluate the effects of a complex of nanoencapsulated active ingredients (AcPi), as well as a cosmetic formulation containing AcPi (ShPi and HtPi) in mechanisms involving hair loss and follicular aging.

Methods: Human hair follicle dermal papilla cells and human scalp culture were treated with AcPi, ShPi, or HtPi and stimulated with UV radiation or testosterone for further measurement of mitochondrial biogenesis, reactive oxygen species (ROS), β-catenin, dyhidrotestosterone (DHT), collagen XVIIα1 (COL17A1), and cutaneous permeation.

Predicting needlestick and sharps injuries in nursing students: Development of the SNNIP scale.

Aim: To develop an instrument to investigate knowledge and predictive factors of needlestick and sharps injuries (NSIs) in nursing students during clinical placements.

Design: Instrument development and cross-sectional study for psychometric testing.

Methods: A self-administered instrument including demographic data, injury epidemiology and predictive factors of NSIs was developed between October 2018-January 2019.

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti-inflammatory and antioxidant agents to treat hair loss.

Androgenetic alopecia (AGA) and telogen effluvium (TE) are common causes of hair loss, with limited options for treatment. The aim of this study was to determine the efficacy and safety of a new formulation kit (Pielus Anti-hair loss lotion and shampoo) containing anti-inflammatory and antioxidant agents in patients with TE and/or AGA. This was a prospective, single-arm, open-label study with 35 women and 10 men, median age of 44 years, with clinical diagnosis of TE and/or AGA.

Whitening effects of cosmetic formulation in the vascular component of skin pigmentation.

Background: Melanin plays an important role in protecting the skin against the harmful effects of solar radiation, but its abnormal accumulation may become an aesthetic problem, such as melasma and age spots.

Aims: The aim of this study was to evaluate the antiangiogenic and whitening effects of a depigmentation formulation (BLTX) using an in vitro model of human cell and skin culture.

Methods: Human fibroblasts, keratinocytes or melanocytes were treated with BLTX and subjected to oxidative stress by UV radiation or inflammatory stress with IL-1α for quantification of melanin, tyrosinase, endothelin-1, PAR-2, VEGF and iNOS.