Publications by authors named "Maurizio Brigante"
Atypical hemolytic uremic syndrome (aHUS) is a rare and heterogenous disease caused by a disregulation of the alternative pathway of the complement cascade. Specifically, microvascular damage is produced that can lead to acute kidney disease, hemolytic anemia and thrombocytopenia. It accounts for 10% of all hemolytic uremic syndromes and can result in death or in end stage renal disease since the first episode.
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- Severe ADAMTS13 deficiency (activity < 10%) is a key indicator of thrombotic thrombocytopenic purpura, but testing can be slow and is often unavailable.
- A new tool called the PLASMIC score helps evaluate acute patients by estimating their risk for severe ADAMTS13 deficiency based on seven clinical variables.
- In a study of 42 patients, the PLASMIC score demonstrated strong predictive value, with a high Area Under the Curve (AUC) of 0.86, showing its effectiveness in guiding urgent treatment decisions.
Sialadenitis (Iodide Mumps) is a rare complication following the administration of iodinated contrast media. It is characterized by the painless bilateral enlargement of the submandibular salivary glands. The pathogenesis of this adverse reaction remains unclear.
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