Prenylated Flavonoids with Potential Antimicrobial Activity: Synthesis, Biological Activity, and In Silico Study.

Prenylated flavonoids are an important class of naturally occurring flavonoids with important biological activity, but their low abundance in nature limits their application in medicines. Here, we showed the hemisynthesis and the determination of various biological activities of seven prenylated flavonoids, named , with an emphasis on antimicrobial ones. Compounds , , and showed inhibitory activity against human pathogenic fungi.

Modeling Cost, Energy, and Total Organic Carbon Trade-Offs for Stormwater Spreading Basin Systems Receiving Recycled Water Produced Using Membrane-Based, Ozone-Based, and Hybrid Advanced Treatment Trains.

To address water scarcity, cities are pursuing options for augmenting groundwater recharge with recycled water. Ozone-based treatment trains comprising ozone and biologically activated carbon potentially offer cost-effective alternatives to membrane-based treatment, the standard process for potable reuse in numerous countries. However, regulations in multiple states effectively limit the extent to which ozone-based treatment alone can produce recycled water for groundwater recharge.

Biotransformation of geranylated- and acetylated-phloroglucinols by Gibberella fujikuroi into molecules with increased antifungal activity against Botrytis cinerea.

Terpenylated phenols possess interesting biological activities. These properties vary mainly according to the type of terpene associated and the degree of oxidation of the molecule. The search for new active molecules for application in different areas of knowledge includes the structural modification of these through ecological methodologies, such as biotransformation.

Antioxidant, phenolic and antifungal profiles of Acanthus mollis (Acanthaceae).

Acanthus mollis is used as ornamental and medicinal plant. The ethnopharmacology reports indicate that extracts have anti-inflammatory activity. Phytoconstituents profile was evaluated by estimating the content of anthraquinones, flavonoids and phenols.

Chemical Composition and Anti-phytopathogenic Activity of the Essential Oil of Beilschmiedia miersii.

Belschmiedia miersii (Gay) Kosterm. (Lauraceae) ("Belloto del Norte") is a little-studied tree endemic of the Central Zone of Chile. Hydrodistillation of leaves and stem bark of B.

Determination of antioxidant properties of 26 Chilean honeys and a mathematical association study with their volatile profile.

Radical scavenging activity (RSA), antioxidant content (TEAC), total phenolic compounds content (TPCC) and volatile profile (VOCs) were measured in 26 honeys obtained from the Valparaiso Region (Chile). Persea americana honey was the most interesting sample according to these evaluated parameters. A Projection to Latent Structures (PLS) based algorithm was used to model the possible relationship between antioxidant activity, total phenolic compounds content and volatile profile.

Synthesis and DPPH radical scavenging activity of prenylated phenol derivatives.

The synthesis of twenty six prenylated phenols derivatives is reported. These compounds were obtained under mild conditions via Electrophilic Aromatic Substitution (EAS) coupling reactions between phenol derivatives containing electron-donor subtituents and 3-methyl-2-buten-1-ol using BF(3)×OEt(2). Dialkylations were also produced with this method.

Amniotic membrane is an immunosuppressor of peripheral blood mononuclear cells.

Unlabelled: Amniotic membrane (AM) is the inner layer of the placenta, which is in contact with the fetus; it has been used for transplantation in ocular surface diseases. It has been reported that amniotic membrane promotes epithelialization, inhibits angiogenesis and diminishes ocular inflammation. A persistent epithelial defect is the delay in epithelial wound healing caused by infiltrating inflammatory cells into the cornea and amniotic membrane transplantation has been successfully used in its treatment, however the mechanism of action in inhibiting inflammation it is not well understood.

Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes.

Premature rupture of chorioamniotic membranes complicated with intrauterine infection has been associated to degradation of extracellular matrix (ECM), which could explain local morphological changes. We used a culture system in which the chorioamniotic membranes form two independent chambers, allowing for the selective stimulation of either the amnion (AMN) and/or the choriodecidua (CHD) regions. Lipopolysaccharide (500 ng/ml) was added to the AMN and/or the CHD; secretions and gelatinolytic activity of matrix metalloproteinase (MMP)-2 and MMP-9 were measured in both compartments by enzyme-linked immunosorbent assay (ELISA) and zymography.