Publications by authors named "Mauricio Cuello Fredes"
Objective: To revise FIGO staging of carcinoma of the cervix uteri, allowing incorporation of imaging and/or pathological findings, and clinical assessment of tumor size and disease extent.
Methods: Review of literature and consensus view of the FIGO Gynecologic Oncology Committee and related societies and organizations.
Results: In stage I, revision of the definition of microinvasion and lesion size as follows.
The gene Oct4 encodes a transcription factor critical for the maintenance of pluripotency and self-renewal in embryonic stem cells. In addition, improper re-activation of Oct4 contributes to oncogenic processes. Herein, we describe a novel designer zinc finger protein (ZFP) capable of upregulating the endogenous Oct4 promoter in a panel of breast and ovarian cell lines carrying a silenced gene.
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- Ovarian cancer is a major health threat, often diagnosed late when it spreads throughout the abdomen, highlighting the need for new treatment strategies.
- Researchers developed an artificial transcription factor (ATF) to enhance the expression of Maspin, a protein that helps suppress metastasis, in aggressive ovarian cancer cell lines.
- The study showed that using ATFs could effectively inhibit tumor growth and invasion in lab models, with promising implications for targeted therapies in advanced ovarian cancer.