Publications by authors named "Maurice Schmutz"
Article Synopsis
- Metamizole, an analgesic, becomes toxic when metabolized to N-methyl-aminoantipyrine (MAA), especially in the presence of heme iron, which affects granulocyte precursor cells.
- In experiments with HL60 cells, the combination of MAA and hemin caused greater ATP depletion than hemin alone, indicating that ATP loss is a key mechanism of MAA/hemin toxicity.
- MAA itself is not toxic at low concentrations but enhances the negative effects of hemin on cellular energy processes, particularly glycolysis, by generating reactive metabolites and reducing pyruvate kinase protein levels.
