Publications by authors named "Mauri D Spendlove"
: Breast cancer is diagnosed in 2.3 million women each year and kills 685,000 (~30% of patients) worldwide. The prognosis for many breast cancer subtypes has improved due to treatments targeting the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
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- A meta-analysis of RNA-sequencing data from patients with different genetic variants showed that tumors with PMS2 mutations have specific active signaling pathways.
- These pathways are linked to cancer growth and spread, suggesting that PMS2 could be key in understanding tumor behavior and might be targeted for new treatments.
Expression of CRIPTO, a factor involved in embryonic stem cells, fetal development, and wound healing, is tied to poor prognosis in multiple cancers. Prior studies in triple negative breast cancer (TNBC) models showed CRIPTO blockade inhibits tumor growth and dissemination. Here, we uncover a previously unidentified role for CRIPTO in orchestrating tumor-derived extracellular vesicle (TEV) uptake and fibroblast activation through discrete mechanisms.
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