Publications by authors named "Maureen S Duffield"
Article Synopsis
- - The study aimed to evaluate the effectiveness and safety of adding corticosteroids to antiretroviral therapy (ART) for patients with HIV-associated nephropathy characterized by specific kidney conditions.
- - Patients were divided into two groups: one receiving ART with corticosteroids and the other on ART alone, followed up for two years, with some showing significant improvement in kidney function (eGFR) in the corticosteroid group.
- - Despite this improvement, the corticosteroid group experienced higher mortality rates, indicating that routine use of corticosteroids cannot be recommended without further research on which patients could potentially benefit.
Human immunodeficiency virus (HIV) infection started in Africa circa 1930. South Africa has the highest prevalence rate in the world. Although reports of HIV-associated nephropathy (HIVAN) appeared in the early 1980s, the earliest report from sub-Saharan Africa (SSA) came in 1994.
View Article and Find Full Text PDFBackground: Two hundred and twenty-one HIV-positive renal biopsies were analysed from Groote Schuur Hospital to determine outcomes and prognostic indicators based on histology and clinical features.
Methods: The histology findings were compared with patient demographics, clinical and renal parameters, mortality, CD4 count and date of commencing combined anti-retroviral therapy (cART). Follow-up was between 1 and 3.