Admixture analysis of age at onset in older patients with schizophrenia spectrum disorders.

The nature of schizophrenia spectrum disorders with an onset in middle or late adulthood remains controversial. The aim of our study was to determine in patients aged 60 and older if clinically relevant subtypes based on age at onset can be distinguished, using admixture analysis, a data-driven technique. We conducted a cross-sectional study in 94 patients aged 60 and older with a diagnosis of schizophrenia or schizoaffective disorder.

Salivary Testosterone Is Consistently and Positively Associated with Extraversion: Results from The Netherlands Study of Depression and Anxiety.

Background: Testosterone has been postulated as a 'social' hormone, but the relationship between testosterone and personality traits linked with socially oriented behaviors such as extraversion remains unclear. The objective of our study was to investigate the association between baseline salivary testosterone levels and the Big Five personality traits.

Methods: We studied the relationship between salivary testosterone (morning and evening) and NEO-FFI (Five-Factor Inventory) personality traits in 1,611 participants with lifetime or current depression and/or anxiety and 482 participants without depression/anxiety of the Netherlands Study of Depression and Anxiety (NESDA).

Schizophrenia spectrum disorders in later life: prevalence and distribution of age at onset and sex in a dutch catchment area.

Objectives: The prevalence of schizophrenia in later life is affected by both outflow of early onset patients, due to recovery and excess mortality, and inflow of patients with a later age at onset, making it likely that characteristics of older patients differ markedly from younger patients. We assessed the prevalence of schizophrenia and spectrum disorders and their distribution according to age at onset and sex in an elderly population.

Design: Case register study.