Publications by authors named "Maureen Joseph"
Multiple heart-cutting and comprehensive two-dimensional liquid chromatography hyphenated to mass spectrometry for the characterization of the antibody-drug conjugate ado-trastuzumab emtansine.
J Chromatogr B Analyt Technol Biomed Life Sci
October 2016
Article Synopsis
- * These ADCs have complex structures, which challenge current techniques in chromatography and mass spectrometry for analysis.
- * The paper discusses using advanced multidimensional liquid chromatography paired with high-resolution mass spectrometry to effectively evaluate important characteristics of ADCs, such as drug loading and distribution.
An ambient extraction of goldenseal root powder followed by HPLC analysis of the alkaloids on a Zorbax Rapid Resolution Eclipse XDB-C18 column provides an accurate method for the determination of key alkaloids in goldenseal, including berberine and hydrastine. The extraction and HPLC analysis can be applied to several other alkaloids, including canadine, hydrastinine, and palmatine, and may be applicable to other berberine-containing plant roots. The Rapid Resolution Eclipse XDB-C18 column is used for an isocratic separation with high resolution of all componentsin under 15 minutes.
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