Publications by authors named "Maureen DeGrange"
Neutrophils collectively migrate to sites of injury and infection. How these swarms are coordinated to ensure the proper level of recruitment is unknown. Using an ex vivo model of infection, we show that human neutrophil swarming is organized by multiple pulsatile chemoattractant waves.
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- Research on COVID-19 vaccination in immune-deficient people largely centers on cancer and organ transplant recipients, showing that 88% developed antispike IgG after the second vaccine dose, increasing to 93% by six months post-third dose.
- However, the antibody levels in immune-deficient patients were significantly lower than those in healthy volunteers, never exceeding one-third of their levels.
- The study suggests that while three doses of the vaccine generate an antibody response, additional doses may be necessary for improved protection, especially against the Omicron BA.1 variant, warranting further investigation into the effectiveness of booster shots.
Neutrophils exhibit self-amplified swarming to sites of injury and infection. How swarming is controlled to ensure the proper level of neutrophil recruitment is unknown. Using an model of infection, we find that human neutrophils use active relay to generate multiple pulsatile waves of swarming signals.
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