Prompt and Appropriate Antimicrobial Therapy Improves Outcomes of NDM-Producing and KPC-Producing Bloodstream Infections in Patients Hospitalized for COVID-19: A Comparative Retrospective Case-Series.

Secondary bloodstream infections (BSIs) caused by KPC- and NDM-producing () during the course of COVID-19 infections lead to significant mortality. Herein, a comparative retrospective case series of KPC- or NDM- BSIs occurring in COVID-19 subjects treated with Ceftazidime/Avibactam (CAZ/AVI) for KPC-, or CAZ/AVI+ Aztreonam (ATM) for NDM-K.p is reported.

An outbreak of HIV-1 BC recombinants in Southern Italy.

Background: In Western Europe, a previously subtype B HIV-1 restricted area, BC recombinants have been rarely reported.

Objective: To describe an outbreak of HIV-1 BC recombinants in southern Italy.

Study Design: We analyzed pol (protease/reverse transcriptase) sequences from 135 newly diagnosed HIV-1-infected patients during the years 2009-2011.

Impact of mutations outside the V3 region on coreceptor tropism phenotypically assessed in patients infected with HIV-1 subtype B.

HIV coreceptor tropism (CTR) testing is a prerequisite for prescribing a coreceptor antagonist. CTR is increasingly deduced by analyzing the V3 loop sequence of gp120. We investigated the impact of mutations outside V3 on CTR as determined by the enhanced-sensitivity Trofile assay (ESTA).