Publications by authors named "Maura R Munoz"
We performed a qualitative review of treatment studies of binge eating disorder (BED), focusing on randomized clinical trials (RCTs). Limited effectiveness has been demonstrated for self-help strategies, and substantial effectiveness has been shown for cognitive behavioral therapy (CBT) and interpersonal therapy (IPT). CBT and IPT may each be more effective than behavior weight loss therapy (BWLT) for reducing binge eating over the long term.
View Article and Find Full Text PDFThe coexpression of the MLL partial tandem duplication (PTD) and the FLT3 internal tandem duplication (ITD) mutations associate with a poor outcome in cytogenetically normal acute myeloid leukemia (AML). In mice, a double knock-in (dKI) of Mll(PTD/wt) and Flt3(ITD/wt) mutations induces spontaneous AML with an increase in DNA methyltransferases (Dnmt1, 3a, and 3b) and global DNA methylation index, thereby recapitulating its human AML counterpart. We determined that a regulator of Dnmts, miR-29b, is downregulated in bone marrow of dKI AML mice.
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- Podocytes are complex cells that play a key role in kidney filtration, and their structural integrity is crucial for preventing glomerular diseases.
- A study purified and analyzed proteins associated with podocyte structures, confirming known proteins like podocin and nephrin, but did not find enrichment of podocalyxin.
- The research highlighted chloride intracellular channel protein 5 (CLIC5) as a new key component essential for maintaining podocyte structure and function, with CLIC5 deficiency leading to significant foot process abnormalities and proteinuria in mice.