Publications by authors named "Maura K Schwartz"
Article Synopsis
- Neuroinflammation plays a significant role in worsening neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), but existing treatments focusing only on this inflammation have not been effective in clinical trials.
- Previous research has shown that correcting motor neurons and astrocytes improves ALS outcomes, yet mice still face mortality due to persistent inflammation, indicating a need for a more comprehensive approach.
- The study introduces a new treatment combining galectin-1 to target microglia with AAV9-mediated SOD1 suppression, resulting in reduced inflammation and improved survival rates in ALS mouse models, emphasizing the importance of addressing inflammatory microglia in future therapies.
Anc80L65 is a synthetic, ancestral adeno-associated virus that has high tropism toward retinal photoreceptors after subretinal injection in mice and non-human primates. We characterized, for the first time, the post-intravitreal cell-specific transduction profile of Anc80L65 compared with AAV9. Here we use Anc80L65 and AAV9 to intravitreally deliver a copy of the gene encoding GFP into WT C57Bl/6J mice.
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