Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading to Cascade Diagnosis for Multiple Generations.

NM_000141.5: FGFR2 c.1032G>A is a pathogenic variant that causes Crouzon syndrome through activation of a new donor splice site.

Changes in orthopaedic prescribing patterns of gabapentin associated with state prescribing restrictions: A large database study.

Background: Safety concerns have emerged regarding gabapentin, and as a result several states have recently adopted regulations for prescribing gabapentin. As gabapentin has been commonly used off-label for pain management in orthopedics, a retrospective analysis was conducted to investigate trends in orthopedic prescriptions of gabapentin considering novel state regulations.

Methods: The study analyzed gabapentin prescription patterns of orthopedic surgeons from 2013 to 2021 recorded in annual Medicare Part D Public Use Files across the fifty states and Washington DC.

Postoperative laboratory testing in the era of outpatient total joint arthroplasty: Targeted patient selection and associated cost savings.

Background: With the advent of outpatient total joint arthroplasty (TJA), the days of routinely drawing postoperative labs (complete blood counts [CBCs] and metabolic panels [CMPs/BMPs]) to monitor for complications are behind us. However, there does exist a subset of at-risk patients that may benefit from diligent postoperative monitoring, though the circumstances under which labs should be ordered remains unclear and subject to surgeon discretion. A systematic review of the literature was therefore conducted to evaluate the utility of postoperative laboratory testing, approaches to targeted patient selection and associated cost-savings.

Assessing the Readability of Clinical Trial Consent Forms for Surgical Specialties.

Introduction: To evaluate the readability of surgical clinical trial consent forms and compare readability across surgical specialties.

Methods: We conducted a cross-sectional analysis of surgical clinical trial consent forms available on ClinicalTrials.gov to quantitatively evaluate readability, word count, and length variations among different specialties.

What Factors Are Associated with Clinical Trial Discontinuation in Orthopaedic Surgery: An Analysis of Clinical Trials Between 2007 and 2022.

Background: Clinical trials play a crucial role in advancing medical knowledge and have the potential to change standards of care. The present study evaluated the prevalence of discontinued clinical trials in orthopaedic surgery. Additionally, we sought to identify the study characteristics associated with and the rationale behind trial discontinuation.