Publications by authors named "Maura E Jones Pullins"

The optimal aspirin dose for preeclampsia prevention remains controversial, with international guidelines lacking consensus on the most effective regimen. Aspirin is a proven intervention for reducing the risk of preeclampsia, particularly when initiated early in pregnancy. Its benefits stem from the selective inhibition of cyclooxygenase-1 (COX-1), reducing thromboxane A2 synthesis while preserving prostacyclin production, thereby restoring the vascular balance essential for placental health.

View Article and Find Full Text PDF
Article Synopsis
  • The best aspirin dose for preventing preeclampsia is still debated, with no global agreement on the ideal regimen.
  • Aspirin works by selectively blocking COX-1, helping maintain blood vessel health in the placenta, and higher doses (≥100 mg) are more effective than lower ones.
  • New research indicates that certain factors, like pregnancy-related changes and obesity, may make lower doses less effective, but a 162 mg dose has proven to be more effective without increasing safety concerns compared to the commonly used 81 mg.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionpnqv2or92jo6sr6qjvj067tkq4v74gft): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once