Publications by authors named "Maura E Jones Pullins"
Aspirin dosage for preeclampsia prophylaxis: an argument for 162-mg dosing.
Am J Obstet Gynecol MFM
January 2025
The optimal aspirin dose for preeclampsia prevention remains controversial, with international guidelines lacking consensus on the most effective regimen. Aspirin is a proven intervention for reducing the risk of preeclampsia, particularly when initiated early in pregnancy. Its benefits stem from the selective inhibition of cyclooxygenase-1 (COX-1), reducing thromboxane A2 synthesis while preserving prostacyclin production, thereby restoring the vascular balance essential for placental health.
View Article and Find Full Text PDFAspirin dose for preeclampsia prophylaxis: an argument for 162-mg dosing.
Am J Obstet Gynecol MFM
November 2024
Article Synopsis
- The best aspirin dose for preventing preeclampsia is still debated, with no global agreement on the ideal regimen.
- Aspirin works by selectively blocking COX-1, helping maintain blood vessel health in the placenta, and higher doses (≥100 mg) are more effective than lower ones.
- New research indicates that certain factors, like pregnancy-related changes and obesity, may make lower doses less effective, but a 162 mg dose has proven to be more effective without increasing safety concerns compared to the commonly used 81 mg.